ASQUE is a novel analgesic combination containing Tramadol, Paracetamol, Caffeine and Taurine.

When a person suffers from pain he/she looks for the following benefits

• Immediate relief from pain
• Severity of pain must be controlled
• Lethargy (caused by severe pain) must be taken care of
• Sense of wellbeing must be achieved

with the synergistic combination of ASQUE Tablets that contains:

CAFFEINE		Ensures Alertness
TRAMADOL		Controls Severity of Pain
PARACETAMOL		Assures QUick onset of Pain relief
TAURINE		Provides Energy for faster rehabilitation

Asque Tablets takes care of most of the menace caused by pain. Apart from that goodness of Taurine also takes care of oxidative stress caused by severe pain.

Multimodal analgesia or balanced analgesia means using a combination of various analgesics in form of combination or individual. The advantages of multimodal or balanced analgesia are:-

• Acts on multiple points in pain pathway – effective analgesia.
• Since multiple analgesics used therefore lower dose requirement of individual analgesics hence less adverse effects.
• Use of paracetamol and NSAIDs has demonstrated to reduce pain score and opioid demand thereby reducing adverse effects caused by opioids namely sedation, mental clouding, respiratory depression and abuse.
• Effective analgesia – Improve mobility, quicker rehalitation.

The other major benefits of Taurine are:-

• Membrane Stabilisation – Taurine’s ability to stabilize cell membranes may be attributed to several events. Taurine has been shown to regulate osmotic pressure in the cell, maintains homeostasis of intracellular ions and water and electrolyte balance.
• Calcium Flux- Taurine is both intracellular and extracellular calcium regulator. Excessive accumulation of intracellular calcium ultimately leads to cell death. Excessive accumulation of calcium into cells has been demonstrated in various types of myocardial (heart muscle) injury, migraines and prolonged epileptic episodes. Taurine supplementation has been shown to be cardioprotective.
• Cardiovascular disease – Taurine is a safe, effective therapeutic tool in the management of various types of cardiovascular disease. Taurine inhibits cardiac arrhythmia, lowers blood pressure and cholesterol levels. In addition it regulates intracellular calcium levels thereby protecting heart muscle from intracellular calcium imbalances, which can lead to cell death and subsequent myocardial damage.
• Taurine has antioxidant properties.
• Diabetes - Taurine supplementation is effective in managing some of the complications of IDDM. Taurine has been found to influence blood glucose, insulin levels, as well as increasing glycogen synthesis and may be involved in the functioning and integrity of pancreatic beta cells.

Caffeine is a mild CNS stimulant and may enhance analgesic efficacy of Tramadol and Paracetamol. It will reduce drowsiness and possibility of respiratory depression that may be caused by Tramadol.

ASQUE is indicated for the management of moderate to moderately severe acute or chronic pain including:-

• OSTEOARTHRITIC PAIN.
• SEVERE LOWER BACK PAIN.
• REHABILITATION AFTER SPORTS INJURY/DAY CASE SURGERY.
• POST OPERATIVE PAIN – GYNAECOLOGIC, OBSTETRIC, ONCOLOGIC, DENTAL SURGERY AND GENERAL SURGERY. FRACTURE.
• NEUROPATHIC PAIN.
• DENTAL PAIN.
• CANCER PAIN

Currently we are the only company in the world to have come out with this combination.

Please go through the drug profile in “Composition” section of ASQUE or consult your doctor.